BALANITES KERNEL OIL FOR THE TREATMENT OF DERMATOPHYTES: A CLINICAL TRIAL

  • Abdalla Mohamed Toum Faculty of Medicine, University of Gezira, Wad Medani, Sudan.(e.mail : drabdaltoum@yahoo.com)
  • Nour Ahmed Osman Biotechnology Centre, Faculty of Engineering and Technology, University of Gezira, Wad Medani, Sudan
  • Elnour Elamin Abdelrahman Biotechnology Centre, Faculty of Engineering and Technology, University of Gezira, Wad Medani, Sudan
  • Ismail Hassan Hussein National Oilseed Processing Research Institute, University of Gezira, Wad medani, Sudan.
  • Salah Ahmed Elhussein National Oilseed Processing Research Institute, University of Gezira, Wad medani, Sudan.

Abstract

In a previous in vitro study, we have shown that the kernel oil of fruits of the tree Balanites aegyptiaca referred to as Balanites kernel oil ((BKO) is active against dermatophytes (i.e. superficial mycosis, ringworms, tineas (T. captitis, T. cercinata and T. pedis). We report here our clinical trials with BKO. Trials were performed on patients presenting at Wad Medani Dermatology Teaching Hospital as well as primary school children in Elsoreeba Town (5 km south of Wad Medani). Not all patients followed treatment till completely cured. Patients treated with BKO (half of the total) achieved complete cure in 3-5 weeks, on average, while those treated with the standard antifungal drug Miconazole (half of the total patients) did the same in the longer period of 3-8 weeks. Photographs showing progress of response to BKO treatments are included. BKO has great potential for development as a commercial drug for the treatment of dermatophytes.

References

1. Rook, A., Wilkinson, D.S., Ebling, F.J.G. Champoin, R.H. and Burton, J.L. (1988). Texbook of Dermatology, Vol.1. 4th ed. Blacwell Scientific Publications.
2. Hunter, J.A.A., Savin; J.A. and Dahl, M.V. (1995). Clinical Dermatology, 2nd ed. Blackwell Scientific Publications.
3. Ahmed, M.A. (2004). History of dematorology in the Sudan. Sudanese Journal of Dermatology, 2(1), 5 Pp.
4. Hainer, B.L. (2003). Dermatophyte infections. American Family Physician (American Academy of Family Physicians) Issue: Jan 1, 10 pp.
5. Abdel-Rahman, S.M. (1997). Ann. Pharmacother, 31: 338-348.
6. Aly, R. (1999). Ecology, epidemiology and diagnosis of Tinea capitis. Prediatr Infect Dis J. 18: 180-185.
7. Evans, E.G. (1997). Tinea pedis. Clinical experience and efficacy of short treatment. Dermatology 194 (Suppl. 1) 3-4.
8. Friedlander, S.E. (2000). Tinea capitis: a current persepective, J. Am. Acad. Dermatol; 17: 325-326.
9. Osman, N.A. (2001). Indigenous Sudanese Balanites aegyptiaca (L.) Del. and Trigonella foenmgraecum L.: An evaluation of their steroidal saponins and other potential economic by-products. Ph.D. Thesis, Faculty of Engineering and Technology, University of Gezira, Wad Medani, Sudan.
10. Osman, N.A., Elhussein, S.A., Abdelrahman, E.E., Hussein, I.H. and Toum, A.M. (2006). In vitro studies on the potentiality of Balanites oil in the treatment of some superficial mycosis. Gezira Journal of Health Science. 2(4), 11 pp.
11. AOCS: Official Methods and Recommended Practices of the American Oil Chemists Society (AOCS) (1973). AOCS Press, Champaigne, IL. (USA), 2nd ed.
12. Elewski, B.E. (2000). Tinea capitis: a current perspective. J. Am Acad. Dermatol; 42 (1 pt 1): 1-20.
Published
2006-06-01
How to Cite
MOHAMED TOUM, Abdalla et al. BALANITES KERNEL OIL FOR THE TREATMENT OF DERMATOPHYTES: A CLINICAL TRIAL. Gezira Journal of Health Sciences, [S.l.], v. 2, n. 1, june 2006. ISSN 1810-5386. Available at: <http://37.60.236.48/index.php/gjhs/article/view/540>. Date accessed: 03 june 2026.
Section
Articles