The Accuracy of FNAC for Diagnosis of Breast Carcinoma in Gezira State, Central Sudan

  • DiaaEldinn Yaseen Salman Assistant professor, Faculty of Medicine, University of Gezira
  • ElGaili Mohamed ElGaili Department of Pathology, Faculty of Medicine, University of Gezira
  • Khalid Eltahir Khalid Department of Biochemistry and Nutrition, Faculty of Medicine, University of Gezira
  • Gamal Mustafa. A. Department of Biochemistry and Nutrition, Faculty of Medicine, University of Gezira
  • Smai . M. Taha Assistant professor, Faculty of Medicine, University of Gezira

Abstract

Background: Breast cancer is a leading cause of death in many countries worldwide and breast lesions remain a common diagnostic dilemma. Fine-needle aspiration cytology (FNAC) has been suggested as the most important, first line, minimally invasive procedure in the management of patients with breast lesions.


Objective: The aim of this study is to assess the diagnostic efficacy of breast FNAC in patients with breast lesions compared with that of the definitive histological diagnasis.


Materials and Methods: This is a hospital-based retrospective study of 112 breast FNAC samples were carried out at Cancer Institute in Medani Gezira state.


 FNAC findings were correlated with data from histopathology records to determine the sensitivity and specificity of FNAC.


Results: Age group of the patients ranged from 26 to 80 years with mean of 42 years. Among the study subjects (112 case), ductal carcinoma is the common hitological finding 83/88 (94%). According to the cytology, 79% were malignant, 4% were benign and 2% were suspicious. Histological correlation was done in 68 cases. The overall diagnostic accuracy of FNAC was 92.3%, with sensitivity and specificity of 89.2% and 66.5% respectively. 


Conclusion: FNAC of breast is asimple, cost effective and less traumatic method for diagnosing breast cancer. It is highly sensitive and accurate, and can reduce the needs for open biopsies. It is recommended that FNAC should be used as a first line method for determining the nature of breast lumps.


 

References

1. Fatima S, Faridi N, Gill S. Breast Cancer: Steroid Receptors Prognostic and other Prognostic Indicators. JCPSP 2005; 15 (4): 230-233.
2. Zafar N, Jamal S, Mamoon N, Luqman M, Anwar M. Typing and Grading of Cytological Category C5 Bre-ast Lesions. JCPSP 2005; 15 (4): 221-224.
3. Putti TC, Pinder E, Elston CW, Lee AHS, Ellis IO. Breast pathology practice: most common problems in a consultation service. Histopathology 2005; 47: 445-457.
4. Clarke D, Sudhakaran N, Gateley CA. Replace fine needle aspiration cytology with automated core biopsy in the triple assessment of breast cancer. Ann R Coll Surg Engl 2001; 83 (2): 110-2.
5. Zafar N, Jamal S, Mamoon N, Luqman M. Cytohistological Correlation of C3 and C4 Breast Lesions. JCP-SP 2005; 15 (4): 196-199.
6. Ahmed I, Nazir R, Chaudharey MY, Kundi S. Triple assessment of breast lump. J Coll Physicians Surg Pak 2007; 17 (9): 535-8.
7. Nggada HA, Tahir MB, Musa AB, Gali BM, Mayun AA, Pindiga UH et al. Correlation between histopathalogic and fine needle aspiration cytology diagnosis of palpable breast lesions: a five years review. Afr J Med Sci 2007; 36 (4): 295-8.
8. Oyama T, Koibuchi Y, McKee G. Core needle biopsy (CNB) as a method for breast lesions; comparison with fine needle aspiration cytology (FNA). Breast Cancer 2004; 11 (4): 339-42.
9. O’Neil S, Castelli M, Gattuso P, Kluskens L, Madsen K, Aranha G. Fine-needle aspiration of 697 palpable breast lesions with histopathological correlation. Surgery 1997; 122 (4): 824-8.
10. McManus DT and Anderson NH. Fine needle aspiration cytology of the breast. Current Diagn Pathol 2001; 7: 262-271.
11. Mehmood A, Ahmed M, Jamal S. Role of cytological grading in the management of breast lump. J Coll Physicians Surg Pak 2003; 13 (3): 150-2.
12. Zagorianakou P, Fiaccavento S, Zagorianakou N, Makredima G, Stefanou D, Agnantis NJ. FNAC: its role, limitations and perspective in the preoperative diagnosis of breast cancer. Eur J Gynaecol Oncol 2005; 26 (2): 143-9.
13. Ishikawa T, Hamaguchi Y, Tanabe M, Momiyama N, Chishima T, Nakati Y et al. False-positive and false-negative cases of fine-needle aspiration cytology for palpable breast lesions. Breast Cancer 2007; 14 (4): 388-92.
14. Berner A, Davidson B, Sigstad E, Risberg B. Fine-needle aspiration cytology vs core biopsy in the diagnosis of breast lesions. Diagn Cytopathol 2003; 29 (6): 344-8.
15. Martin HE, Ellis EB. Biopsy by needle puncture and aspiration. Ann Surg 1930; 92:169-81.
16. Tariq GR, Haleem A, Zaidi AH, Afzal M, Abbasi S. Role of FNA Cytology in the Management of Carcinoma Breast. JCPSP 2005; 15 (4): 207-210.
17. Hussain MT. Comparison of Fine Needle Aspiration Cytology with Excision Biopsy of Breast Lump. JCP-SP 2005; 15 (4): 211-214.
18. Bajwa R and Zulficar T. association of fine needle aspiration cytology with tumor size in palpable breast lesions. Biomedica 2010; 26: 124-129.
19. Yong WS, Chia KH, Poh WT, Wong CY. A comparison of trucut biopsy with fine needle aspiration cytology in the diagnosis of breast cancer. Singapore Med J. 1999 Sep; 40(9):587-9.
20. Francis IM, Das DK. Role of Fine Needle Aspiration, Intraoperative Imprint Cytology and Frozen Section in the Diagnosis of Breast Lumps and Thyroid Lesions Medical Principles and Practice 1999, Vol. 8 (3): 173-182.
21. Dutta SK, Chattopadhyaya A, Roy S. Evaluation of fine needle aspiration and imprint cytology in the early diagnosis of breast lesions with histopathological correlation. J Indian Med Assoc. 2001 Aug; 99(8):421-3.
Published
2018-06-19
How to Cite
SALMAN, DiaaEldinn Yaseen et al. The Accuracy of FNAC for Diagnosis of Breast Carcinoma in Gezira State, Central Sudan. Gezira Journal of Health Sciences, [S.l.], v. 9, n. 2, june 2018. ISSN 1810-5386. Available at: <http://37.60.236.48/index.php/gjhs/article/view/421>. Date accessed: 03 june 2026.
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Vol 9 No 2 (2013)
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