Clinical Presentation and Histopathological Patterns of Renal Cell Carcinoma in Gezira Hospital for Renal Diseases and Surgery

  • Salih Yahia Mohammed MD of General Surgery
  • Mustafa Omran Mansour MD of General Surgery, Consultant of Urology Gezira Hospital for Renal diseases & Surgery.
  • Mohammed Elemam Mohammed Ahmed MD of General Surgery, Professor of urology Gezira hospital for renal diseases & surgery

Abstract

Background: Renal cell carcinoma (RCC) is the most common primary tumour of the kidney in adults, responsible for (80-85%) of renal tumours (1). Due to the absence of studies in Sudan in assessing the pattern and presentation of RCC, we conducted this retrospective study in Gezira Hospital for Renal Diseases and Surgery, in the period from January 2006 to January 2012. 


Objective: To determine the clinical presentation, pathological pattern and stages of RCC in patients who were treated in (GHRS) in the period of this study.


Results: A total of 60 patients were diagnosed as RCC in the period of six years. The disease was more common in males, with a peak incidence in the fifth and sixth decades. The classical triad were observed in 19 patients .Mean duration of symptoms was 4 months. Some patients had metastasis in the lung, bones or liver at diagnosis. Most of the patients presented with haematuria (66.6%), a small number with cervical lymphadenopathy (6.7%), lower limb edema (3.3%) and non reducible varicocele (5%).


conclusion: A large number of patients presented with a palpable loin mass, in contrast incidentally diagnosed cases were few .The age of presentation is one decade earlier than that in the western world.

References

1. Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nat Rev Urol ; 7:245.
2. Mandel JS, McLaughlin JK, Schlehofer B, et al. International renal-cell cancer study. IV. Occupation. Int J Cancer ; 61:601.
3. Wolk A, Gridley G, Niwa S, et al. International renal cell cancer study. VII. Role of diet. Int J Cancer 1996; 65:67.
4. Maclure M. Asbestos and renal adenocarcinoma: a case-control study. Environ Res 1987; 42:353.
5. McLaughlin JK, Blot WJ, Mehl ES, et al. Petroleum-related employment and renal cell cancer. J Occup Med ; 27:672.McLaughlin JK, Blot WJ, Mehl ES, et al.
6. Kolonel LN. Association of cadmium with renal cancer. Cancer 1976; 37:1782.
7. Brauch H, Weirich G, Hornauer MA, et al. Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma. J Natl Cancer Inst ; 91:854.
8. Richie JP, Skinner DG. Renal neoplasia. In: The Kidney, 2nd, Brenner BM, Rector F (Eds), WB Saunders, Philadelphia 1981. p.2109.
9. Tannenbaum M. Ultrastructural pathology of human renal cell tumors. PatholAnnu ; 6:249.
10. Patard JJ, Leray E, Rioux-Leclercq N, et al. Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J ClinOncol ; 23:2763.
11. Presti JC Jr, Rao PH, Chen Q, et al. Histopathological, cytogenetic, and molecular characterization of renal cortical tumors. Cancer Res ; 51:1544
12. Zisman A, Chao DH, Pantuck AJ, et al. Unclassified renal cell carcinoma: clinical features and prognostic impact of a new histological subtype. J Urol ; 168:950.
13. Karakiewicz PI, Hutterer GC, Trinh QD, et al. Unclassified renal cell carcinoma: an analysis of 85 cases. BJU Int ; 100:802.
14. Nguyen MM, Gill IS, Ellison LM. The evolving presentation of renal carcinoma in the United States: trends from the Surveillance, Epidemiology, and End Results program. J Urol ; 176:2397.
15. Campbell-Walsh, Urology, Louis R. Kavoussi, Alan W. Partin, Andrew C. Novick, Craig A. Peters,. Malignant renal tumor. Tenth ed. Philadelphia: Elsevier,Saunders; .1419-1438
16. Smith’s General Urology, Emil A. Tanagho, Jack W. McAninch,s. Renal Parenchymal Neoplasms:17th ed. McGraw-Hill Companies; .328-335
17. K.H. Tijani, C. C. A., E.V. Ezenwa,A. Lawal et al). "Adult renal cell carcinoma in Lagos: Experience and challenges at the Lagos University Teaching Hospital." African Journal of Urology 18(1): 20-23.
18. PR,, Shrestha GK SG, Joshi BR. Pattern of Renal Cell Carcinoma Sidharth LB, Gupta DK, Maskey P, Chalise PR, Sharma UK, Gyawali – A Single CenterExperience in Nepal. Kathmandu Univ Med J. ;35(3):185-8
19. M.M. Marberger, L. B., C.R. Chapple. "Renal Cell Carcinoma." Official Journal of the European Association of Urology 4(1): 189-194
20. T.A.Badmus, A. B., Salako,F.A.Arogundade,et al. "Malignant Renal Tumors in Adults:ATen Year Review in Nigerian Hospital." Saudi Journal of Kidney Diseases and Transplant 19(1): 120-126
Published
2013-12-01
How to Cite
MOHAMMED, Salih Yahia; MANSOUR, Mustafa Omran; MOHAMMED AHMED, Mohammed Elemam. Clinical Presentation and Histopathological Patterns of Renal Cell Carcinoma in Gezira Hospital for Renal Diseases and Surgery. Gezira Journal of Health Sciences, [S.l.], v. 9, n. 2, dec. 2013. ISSN 1810-5386. Available at: <http://37.60.236.48/index.php/gjhs/article/view/413>. Date accessed: 03 june 2026.
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Articles