INFLUENCE OF MILK AND SOME SUDANESE MEALS ON THE DISSOLUTION OF CIPROFLOXACIN TABLETS
Abstract
For a drug to be effective , it must be released from the dosage form , fully dissolved in the gastro-intestinal fluids , be stable as solution in the gastro-intestinal fluids, pass through the gastrointestinal barriers into the mesenteric circulation without being metabolized , pass through the liver into the systemic circulation unchanged and reach its site of action.
Food is one of the factors which interfere with these processes. The effect of Sudanese meals will be different due to their high contents of fats, proteins and fibers
This study aimed to determine the influence of milk and some Sudanese meals
(Foul –Vicia faba - , “Gorrassah with damaa” and “ Kissraa with sharmoot” )on the dissolution of ciprofloxacin HCl tablets and hence bioavailability.
The influence of milk and the mentioned Sudanese meals on the dissolution of ciprofloxacin was studied using paddle dissolution apparatus. The dissolution of the drug was measured in the presence of each meal individually using U.V- visible spectrophotometer. The samples were taken with 5 minutes intervals up to 30minutes The results obtained were compared to the results of the dissolution of this drug in simulated gastric fluid in fast state [0.1 N HCl].
The study revealed that the dissolution of ciprofloxacin in Sudanese meals is lower than its dissolution in milk- whose reduction of dissolution of ciprofloxacin was mentioned in a lot of studies world-wide. The order of the influence of Sudanese meals, used in the study, was foul followed by kissraa then gorrasah which showed that the influence was directly proportional to the viscosity of the meal. Using two different volumes of foul ,the study revealed that influence of meals on the dissolution of ciprofloxacin was significant even small amounts were used.
References
2-Aulton, ME (2002): The science of dosage form design, 2nd edition, Churchill Livingstone. Spain, p: 213-256.
3-Subrahmanyam, CV and Setty JT (2001): Laboratory Manual of Physical Pharmaceutics 1st ed., Vallabh Prakashan , p: 141-147.
4-Homeida, MM ; Ali, HM ; Bennett, JL and Mahmoud, BM (1994): Significant reduction in chloroquine bioavailability following co-administration with the Sudanese beverages Aradaib, Karkadi and Lemon. Antimicrobial chemotherapy J., 33: 1005-1009.
5-Abdelgadir, M; Abbas, M; Järvi, A; Elbagir, M; Eltom, M and Berne, C (2005): Glycaemic and insulin responses of six traditional Sudanese carbohydrate-rich meals in subjects with type 2 diabetes mellitus: Diabetic Medicine J., 22: 213–217.
6-British Pharmacopoeia , 2005.
7-FDA (2002): Guidance for industry, Food-effect bioavailability and Fed Bioequivalences studies.
8- Shargel, L and Yu, A (1999): Applied biopharmaceutics and pharmacokinetics, 4th edition, McGraw – Hill Medical Publishing Division, USA, p: 129-163.
9-Kshirsagar NA and Ankalesaria PS (1987): Effect of food on tetracycline absorption. J. Postgrad. Med, 33: 117-119.
