MEAN PLATELET VOLUME IN TYPE II DIABETES MELLITUS, CASE CONTROL STUDY – GEZIRA CENTRAL SUDAN
Abstract
Aim: Thrombotic disorders are the major complications of diabetes mellitus (DM). Platelets are considered to play a role in these vaso-occlusive complications. The mean platelet volume (MPV) is recently taken as indicator for platelet reactivity. The aim of this study was to show the state of platelet activity in type II diabetes mellitus by indication of MPV.
Methods: This study was done in Wad Madani, Gezira State, Sudan 2007. MPV was measured in 100 adult type II diabetic Sudanese patients and 100 adult healthy control subjects matched for age and gender.
Results: MPV was found to be significantly higher among the diabetic group (mean 9.9 fl) than the control group (mean 9.0 fl) (P value 0.015).
Conclusion: We conclude that elevated MPV may indicate platelet hyperactivity, which may contribute to the vascular complications of type II DM.
References
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12. Sharpe P.C, Trinick T. Mean platelet volume in diabetes mellitus. QJM: An International Journal of Medicine.1993; 86:739-743.
13. Tschope D, Langer E, et al. Increased platelet volume — Sign of impaired thrombopoiesis in diabetes mellitus. Journal of Molecular Medicine, 2005; 67:253-259.
14. Papanas N, Symeonidis G, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets, 2004; 8:475-478.
15. Coban, Erkan, et al. The mean platelet volume in subjects with impaired fasting glucose. Platelets, 2006; 17: 67-69.
16. King H, Aubert RE, Herman WH. Global burden of diabetes. Diabetes Care, 1998; 21: 1414–1431.
17. Bierman E.L. Atherogenesis in diabetes. Arterioscler Thromb, 1992; 12: 647–656.
18. Smith N, Pathansali, Bath P. Platelets and stroke. Vasc Med. 1999; 4: 156-172.
19. Knobler H, Savion N, Shenkman B, et al. Shear-induced platelet adhesion and aggregation on subendothelium are increased in diabetic patients. Thromb Res, 1998; 90: 181–190.
20. Greer J.P, Forester J, Lukens J. N, Rodgers G. M et al. Wintrobe s Clinical Haematology. 11th edition. Lippincott Williams and Wiklins: Philadelphia, London, New York, Tokyo, Hong Kong, 2004; 619,620.
21. Martin J.F. Platelet heterogeneity in vascular disease. Platelet heterogeneity: biology and pathology, 1990; 205–226.
22. Eldor A, Avitzour M, Or R, Hanna R, Penchas S. Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume. BMJ. 1982;285:397–400.
23. Jilma B, Fasching P, Ruthner C, et al. Elevated circulating P-selectin in insulin dependent diabetes mellitus. Thromb Haemost, 1996; 76: 328–332.
2. UK Prospective Diabetes Study Group (UKPDS): Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet, 1998; 352:837 –853.
3. Sobol A.B, Watala C. The role of platelets in diabetes related vascular complications. Diab Res Clin Prac, 2000; 50: 1–16.
4. Colwell J.A, Nesto R.W. Focus on prevention of ischemic events. Diabetes Care, 2003; 26: 2181–2188.
5. Holmsen H. The platelet: its membrane, physiology and biochemistry. Clin Haematol, 1972; 1:235-266.
6. Frank F, Chesterman C, Pennington. D, Ruch B. De'Cruchys Clinical Haematology in Medical Practice. 5th edition. Melburne London. Edinburgh. Berlin. Black Well Sciences, 1989; 24-25,407.
7. Ferroni P, Basilis S, Falco A, Davi G. Platelet activation in type 2 diabetes mellitus. Journal of Thrombosis and Haemostasis, 2004; 2:1282-1291.
8. Queen L.R, J.Y, Goubareva I. Nitric oxide generation mediated by -adrenoceptors is impaired in platelets from patients with type II diabetes mellitus. Diabetologia. 2003; 46: 1474–1482.
9. Bath P. H, Algert Ch et al. Association of Mean Platelet Volume With Risk of Stroke Among 3134 Individuals With History of Cerebrovascular Disease. Stroke, 2004; 35:622.
10. Tavil Y, Sen N, et al. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Sciencedirect, 2007; 120: 245-250.
11. Jagroop I. A, Tsiara S, Mikhailidis D. P. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets, 2003; 14: 335–336.
12. Sharpe P.C, Trinick T. Mean platelet volume in diabetes mellitus. QJM: An International Journal of Medicine.1993; 86:739-743.
13. Tschope D, Langer E, et al. Increased platelet volume — Sign of impaired thrombopoiesis in diabetes mellitus. Journal of Molecular Medicine, 2005; 67:253-259.
14. Papanas N, Symeonidis G, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets, 2004; 8:475-478.
15. Coban, Erkan, et al. The mean platelet volume in subjects with impaired fasting glucose. Platelets, 2006; 17: 67-69.
16. King H, Aubert RE, Herman WH. Global burden of diabetes. Diabetes Care, 1998; 21: 1414–1431.
17. Bierman E.L. Atherogenesis in diabetes. Arterioscler Thromb, 1992; 12: 647–656.
18. Smith N, Pathansali, Bath P. Platelets and stroke. Vasc Med. 1999; 4: 156-172.
19. Knobler H, Savion N, Shenkman B, et al. Shear-induced platelet adhesion and aggregation on subendothelium are increased in diabetic patients. Thromb Res, 1998; 90: 181–190.
20. Greer J.P, Forester J, Lukens J. N, Rodgers G. M et al. Wintrobe s Clinical Haematology. 11th edition. Lippincott Williams and Wiklins: Philadelphia, London, New York, Tokyo, Hong Kong, 2004; 619,620.
21. Martin J.F. Platelet heterogeneity in vascular disease. Platelet heterogeneity: biology and pathology, 1990; 205–226.
22. Eldor A, Avitzour M, Or R, Hanna R, Penchas S. Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume. BMJ. 1982;285:397–400.
23. Jilma B, Fasching P, Ruthner C, et al. Elevated circulating P-selectin in insulin dependent diabetes mellitus. Thromb Haemost, 1996; 76: 328–332.
Published
2010-06-01
How to Cite
ALI, Soad Fadlallah; ALI, Omar Widaa.
MEAN PLATELET VOLUME IN TYPE II DIABETES MELLITUS, CASE CONTROL STUDY – GEZIRA CENTRAL SUDAN.
Gezira Journal of Health Sciences, [S.l.], v. 6, n. 2, june 2010.
ISSN 1810-5386. Available at: <http://37.60.236.48/index.php/gjhs/article/view/271>. Date accessed: 03 june 2026.
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