Prevalence of Hepatitis C Virus (HCV) Antibodies in Patients with Schistosomaisis
Abstract
This study comprised 850 subjects from three villages in the Gezira area in the central regain of the Sudan. Faeces and urine specimens collected from the above subjects were examined for Schistosoma mansoni and S.heamatobium. One hundred and six individuals were confirmed positive, 49 (46.2%) with S.mansoni, 50 (47.2%) were infected with S.heamtobium and 7 ( 6.6%) with mixed infection. Of the 106 serum samples obtained from schistosoma-infected subjects and 100 serum samples from control subjects were tested by ELISA, 33 (31.1%) and 4 (4%) were found reactive for HCV antibodies respectively. These results showed strong association between schistosomaisis and HCV, which may suggest that schistosoma infection is a cofactor in HCV infection in patients with Bilharsiasis. A further study of large population size is highly recommended in order to draw a conclusion in the association between HCV and schistosoma infections.
References
2- Alter , M. J. (1991) . Unapparent transmission of hepatitis C: Foot prints in the sand. Hepatology 11:389-39.
3- colombo, M., Kuo, G.,et al, Prevalence of antibodies to Hepatitis. Lancet 11: 1006- 08.
4- Self. C. H. (1985) Enzyme amplification applied to provide an immune-assisted assay for placental alkaline phosphatase. J.Immunol. Meth. 10:389-393.
5- Kamel, M. A. Ghaffar Y. A. et . al . High HCV prevalence in Egyption donors. Lancet.: 110 :427.
6- Mohamed MK, Bakr I, El-Hoseiny M, Arafa N, Hassan A, Ismail S, Anwar M, Attala M, Rekacewicz C, Zalata K, Abdel-Hamid M, Esmat G, Fontanet A. HCV-related morbidity in a rural community of Egypt. J Med Virol. 2006 Sep;78(9):1185-9
7- Arafa N, El Hoseiny M, Rekacewicz C, Bakr I, El-Kafrawy S, El Daly M, Aoun S, Marzouk D, Mohamed MK, Fontanet A. Changing pattern of hepatitis C virus spread in rural areas of Egypt. J Hepatol. 2005 Sep;43(3):418-24
8- Khan ZA, Alkhalife IS, Fathalla SE. Prevalence of hepatitis C virus among bilharziasis patients. : Saudi Med J. 2004 Feb;25(2):204-6
9- Mudawi HM, Smith HM, Rahoud SA, Fletcher IA, Babikir AM, Saeed OK, Fedail SS.Epidemiology of HCV infection in Gezira state of central Sudan. J Med Virol. 2007 Apr;79(4):383-5.
10- Pereira LMB. Hepatitis C virus in patients with schistosomaisis. J. Med. Virol.:1:2:423-428.
11- Gray, J. J. (1990). Differentiation between specific and non-specific Hepatitis C antibodies in chronic liver disease. Lancet. 335:609-610.
12- Wong, D.C. (1990). Non-specificity of anti-HCV test for seroepidemiological analysis. Lancet, 355:750-751.
13- Jackson, B. J. (1991). Hepatitis C Virus antibody in H 1 V-1 infected Ugandan mothers. Lancet, 111:551.
