BIOCHEMICAL AND CLINICAL ASSESSMENT OF THYROID STATUS IN PATIENTS WITH THYROID DISORDERS REFERRED TO EL-OBIED REGIONAL HEALTH LABORATORY

  • Majdolin Mohammed Eltayeb Department of Biochemistry, Faculty of Medicine, Kordofan University, Sudan
  • Omer Hassan Daoud Department of Paediatrics, Faculty of Medicine, Kordofan University, Sudan.
  • Ahmed Abdalla Ajabeldour Ajabeldour Department Pathology, Faculty of Medicine, Kordofan University, Sudan.
  • Khalid Eltahir Khalid Department of Biochemistry and Nutrition, Faculty of Medicine, University of Gezira, Sudan

Abstract

Objective of this study: This study aimed at assessing the thyroid status in Kordofan region (western Sudan) where the prevalence of goitre was not clearly defined.


Material and Methods: A cross-sectional, prospective study was conducted in Elobied regional health laboratory on 150 thyroid patients (136 female, 14 male) referred during the period between May-November 2003, their ages ranged between 6 to 65 years. A matching control group of 50 subjects (39 female, 11 male) without symptoms or signs of thyroid disease, were included for comparison. After clinical evaluation and data collection through a questionnaire, serum concentrations of TSH, total triiodothyronine (TT3), and total thyroxine (TT4) were measured by radioimmunoassay.


Results: The frequency of thyroid disorders was higher in females (90.7%) than in males (9.3%), among the age group between 25-34 years. The percentage of patients with euthyroid was significantly higher (62%) compared with 28.3% of hyper and 9.3% of hypothyroidism. 69.3% of the thyroid patients had stage ІІ goitre. TT4, TT3 and TSH showed significant differences (P<0.001) in hyper and hypothyroidism compared with the euthyroid patients and the control group. Serum TT4 values correlated negatively with TSH (r = 0.272, P = 0.001), and positively with TT3 (r = 0.693, P = 0.000).


Conclusion: The prevalence of thyroid diseases was found higher in this area, with strong association with the food intake and genetic background, a problem needing to be considered seriously.

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Published
2008-01-01
How to Cite
MOHAMMED ELTAYEB, Majdolin et al. BIOCHEMICAL AND CLINICAL ASSESSMENT OF THYROID STATUS IN PATIENTS WITH THYROID DISORDERS REFERRED TO EL-OBIED REGIONAL HEALTH LABORATORY. Gezira Journal of Health Sciences, [S.l.], v. 4, n. 1, jan. 2008. ISSN 1810-5386. Available at: <http://37.60.236.48/index.php/gjhs/article/view/228>. Date accessed: 03 june 2026.
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