Neonatal Outcome In Severe Malaria with Pregnancy

  • Atif Bashir Fazari Consultant of Obstetrics& Gynaecology Faculty of Medicine The Academy of Medical Sciences& Technology

Abstract

Pregnant women are more vulnerable to malaria, because of changes in the immune system during pregnancy. It is known that malaria infection during pregnancy, induce a potentially harmful response, in the placenta and the fetus. This study designed to determine the outcome of the neonates in cases of severe malaria. Twenty- five cases observed during acute malarial attack proved by positive parasite in peripheral blood film with severe parasitaemia in different time in their third trimester. This observation depends on different parameters studied here. Seven stillborn (28%).  Ten low birth weight (40%). Four with low Apgar score (16%).  Six born prematurely (24%), two of them, ended in early neonatal death.


Further multi central studies with advanced measures recommended studying fetal response during acute attack of malaria.

References

1)Galbraith RM, Fox H, His B, et al: The human materno – foetal relationship in malaria. II. Histological, Ultrastructural and immunological studies of the placenta. Trans R. Soc Trop Med Hyg 74:61,1980.
(2)Moormann AM, Sullivan AD, Rochford RA, Chensue SW, Bock PJ, Nyirenda T,Meshnick SR. Malaria and pregnancy: placenta cytokine expression and relationship to intrauterine growth retardation. J Infect Dis 1999 Dec; 180 (6): 1987-93.
(3)Mutabingwa TK, 1994. Malaria and pregnancy: epidemiology, pathophysiology and control option. Acta Trop 57:239-254.
(4)Nathwani D, Currie PF, Douglas JG, Green ST, Smith NC, 1992.Plasmodium falciparum malaria in pregnancy: a review.Ba J Obstet Gynaecol 99:118-121.
(5)Philippe Arbeille, Gabriel Carles, Franck Bousquet, Gille Body, Jacque Lansac 1998. Fetal cerebral and umbilical artery blood flow changes during pregnancy complicated by malaria. J Ultrasound Med 17:223-229...
(6) Annual report –Minstry of Health- Sudan.2003


(7) Malaria diagnosis new perspectives Report of a joint WHO/USAID informal consultation, 25-27 October 1999

(8) ©Malariasite.com 2002-2004.Dr. B.S. Kakkilaya’s Malaria web site.

(9) Malaria and pregnancy in an area of seasonal and unstable transmission in the eastern Sudan. Dr Gehad Elghazali, MD, PhD.Malaria Research Center, Department of Biochemistry, Faculty of Medicine, University of Khartoum, Sudan.

(10) Pregnancy at risk – Current concepts, Malaria during pregnancy, (chapter 22, 115 – 119)

(11) Brabin, B. J., Maxwell, S., Chimsuku, L., Verhoeff, F., van der Kaay, H. J., Broadhead, R., Kazembe, P. and Thomas, A. (1993). A study of the consequences of malaria infection in pregnant women and their infants. Parasitolgia. 35 (suppl.) 9-11.
Published
2004-01-01
How to Cite
FAZARI, Atif Bashir. Neonatal Outcome In Severe Malaria with Pregnancy. Gezira Journal of Health Sciences, [S.l.], v. 1, n. 1, jan. 2004. ISSN 1810-5386. Available at: <http://37.60.236.48/index.php/gjhs/article/view/155>. Date accessed: 03 june 2026.
Section
Articles