Optimized Synthesis of a Novel 1-(trifluoroethenyl)-4-[(trifluoroethenyl)-oxy]-benzene via Palladium-Catalyzed Coupling of Arylboronic Acids with Bromotrifluoroethylene

Abstract

The synthesis of a novel 1-(trifluoroethenyl)-4-[(trifluoroethenyl)oxy]benzene at  optimized reaction conditions were described. The optimized reaction condition required only 0.25 mol% of Pd(dba)₂ and 0.5 mol% of  ^t-Bu₃-P and occurred to full conversion within 12 h at 80^oC. The   novel product was assayed by ¹H and ¹⁹F NMR spectroscopy.