Antimalarial Activity of Certain Sudanese Medicinal Plants Used in Folk –Medicine
Abstract
Ten indigenous plants of common use in Sudanese folk-medicine, vitro for antimalarial activity against Plasmoclium were examined in falciparum, the major human malaria parasite. All plant samples displayed various antimalarial activity. Three plant extracts caused 100% inhibition of the parasite growth at a concentration ≤ 500 g/ml. The most active extracts that produced 100% inhibition of the parasite growth at a concentration ≤ 50 g/ml were obtained from the seeds of Nigella sativa and the whole plant of Aristolochia bracteolata. These two plants were phytochemically screened for their active constituents and both showed the presence of sterols, alkaloids and tannins.
References
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Antoun, M.D., Z. Ramos, J. Vazques, I. Oquendo, G.R. Proctor and R. Gerena. 2001. Evaluation of the flora of Pueno Rico for the in vitro antiplasmodial and anti-mycobacterial activities. Phytotherapy Research 15 (7): 638-642.
Bray, D.H., J.D. Connolly, W. Peters , J.D. Phillipson, B. L. Robinson, A. Tella, A. Y. Thebtar, D.C. Warhurst and Y. Ynthavong. 1985. Antimaralial activity of some limonoids. Royal Society of Tropical Medicine and Hygiene 79 (3): 426.
Cevdet, N and O. Semih. 1993. Chemical composition of Nigella sativa L. seeds. Food Chemistry 48: 259-261
Christopher, H. 2002. Medicine for malaria venture. Global forum for health research, the 10/9 report on health research 2001-2002, 161- 166 WHO, Geneva, Switzerland.
EL-Tahir, G.M.H. Satti and S. A. Khalid. 1999. Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell Journal of Ethnopharmacology 64:227-233.
Evans, W.C. 1989. Text Book of Pharmacognosy. 13th edition, Bailliere Tindall, London UK.
Gakunju, D. M. N, E.K. Mberu, S. F. Dossaji , A. J. Gray , R.D Waigh P. G. Waterman and W.M. Watkins. 1995. Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy Antimicrobial Agents Chemistry 39 (12): 2606-2609.
Jurg, A. , T. Tomas and J, Pividal. 1991. Antimalarial activity of some plant remedies in use in Maracuene, Southern Mozambique. Journal of Ethnopharmacology 33 (1-2): 79-83.
Khalid, S.A., A. Farouk, T.G.Geary and B. James. 1986. Potential antimalarial candidates from Africa plants: An in vitro approach using Plasmodium falciparum. Journal of Ethnopharmacology 15: 201-209.
Mackinnon, S. , T. Durst, J. T. Arnason, C. Angerhofer, J. Pezzuto, V.P.E. Sanchez, L. J. Poveda and M. Gbeassor. 1997. Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives. Journal of Natural Products 60(4): 336-341
Najib. N.A., N. Rahman, T. Furuta, S. Kojima, K. Takane and M.M, Ali. 1999. Antimalarial activity of extracts of Malaysian medicinal
plants. Journal of Ethnopharmacology 64(3): 249-254.
Nundkumar, N. and J. A. Ojewole. 2002. Studies on the antiplasmodial properties of some South African medicinal plants used as antimalarial remedies in Zulu folk medicine. Clinical Phanmcology 24(7):397-401.
Pena, J. M., M. Borras, J. Ramos and J. Montoliu. 1996. Rapidly progressive interstitial renal fibrosis due to chronic intake of a herb Aristolochia pistolochia infusion. Journal of Nephrology, Dialysis and Transplantation 11: 1359-1360
Phillipson, J.D. and M.J. O'Neill. 1986. Novel antimalarial drugs from plants. Parasitology Today 2 (12): 355-358.
Weenen , H. , M. H. Nkanya , D.H. Bray , L.B. Mwasumbi , L.S. Kinabo and V.A. Kilimali. 1990. Antimalarial activity of Tanzanian medicinal plants. Planta Medica 56 : 386 -- 390
W. H. O., CTD/ Mal/ 97. 20 Rev. 2 2001. In vitro micro-test (Mark 111) for the assessment of the response of Plasmodium falciparum to chloroquine, mefloquine, quinine, amodaquine, sulfadoxine/ pyrimtha- mine and anemisinin, instructions for use of the in vitro micro-test kit )Mark 111(.
Willcox, M. I. 1999. A clinical trial of "AM" Augandan herbal remedy for malaria. Journal of Public Health Medicine 21 (3): 318-324.
Published
2021-08-31
How to Cite
M. AHMED, EL-Hadi; S. KHALID, Hassan; G. MOHAMMED, Yousif G. Mohammed.
Antimalarial Activity of Certain Sudanese Medicinal Plants Used in Folk –Medicine.
Gezira Journal of Agricultural Science, [S.l.], v. 3, n. 1, p. 99-108, aug. 2021.
ISSN 1728-9556. Available at: <http://37.60.236.48/index.php/gjas/article/view/2100>. Date accessed: 03 june 2026.
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